RANK and RANK ligand expression in primary human osteosarcoma
نویسندگان
چکیده
منابع مشابه
RANK and RANK ligand expression in primary human osteosarcoma
Receptor activator of nuclear factor kappa-B ligand (RANKL) is an essential mediator of osteoclast formation, function and survival. In patients with solid tumor metastasis to the bone, targeting the bone microenvironment by inhibition of RANKL using denosumab, a fully human monoclonal antibody (mAb) specific to RANKL, has been demonstrated to prevent tumor-induced osteolysis and subsequent ske...
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BACKGROUND There is no established systemic treatment option for unresectable osteosarcoma progressing after standard chemotherapy. A recently published clinical trial has demonstrated some activity of sorafenib in this situation. Preclinical research suggests a role for the inhibition of the receptor activator of nuclear factor-ĸB ligand (RANKL), but no clinical data have been reported so far....
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ژورنال
عنوان ژورنال: Journal of Bone Oncology
سال: 2015
ISSN: 2212-1374
DOI: 10.1016/j.jbo.2015.06.002